Key result
A 71-year-old man developed a rare and aggressive angiosarcoma of the prostate gland 5 years after receiving permanent interstitial brachytherapy for prostatic adenocarcinoma.
Case Report (n=1)
Highlights a rare case of prostatic angiosarcoma potentially linked to prior radiation therapy for prostatic adenocarcinoma.
Prior radiation for prostate cancer may increase angiosarcoma risk; leaves open optimal management and true incidence with rising radiation use.
Prostatic adenocarcinoma is the most common cancer in men, but only a handful of cases of prostatic angiosarcoma have been reported in the literature. Prior radiation therapy for prostatic adenocarcinoma has been hypothesized to be a risk factor for angiosarcoma. The increasing practice of prostate cancer screening and the use of radiation therapy for management of prostatic adenocarcinoma will likely lead to more cases of prostatic angiosarcoma. Diagnosis is made by tissue sampling. Optimal management of these aggressive tumors remains to be defined and outcomes are poor with a high 1-year mortality. Primary care physicians and urologists should be aware of this rare entity and refer these patients to specialist centers where they can be managed by a multidisciplinary team. We report a case of angiosarcoma of the prostate gland diagnosed in a male presenting with lower urinary tract symptoms 5 years after brachytherapy for prostate adenocarcinoma.
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Gupta et al. (2015) conducted a case report in Prostatic angiosarcoma (n=1). Permanent interstitial brachytherapy was evaluated on Development of prostatic angiosarcoma. A 71-year-old man developed a rare and aggressive angiosarcoma of the prostate gland 5 years after receiving permanent interstitial brachytherapy for prostatic adenocarcinoma.
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