Genetic loci associated with circulating levels of very long-chain saturated fatty acids
Key result
Common genetic variants in SPTLC3 (rs680379) and CERS4 (rs2100944) were significantly associated with circulating levels of arachidic acid (P=5.81×10^-13 and P=2.65×10^-40, respectively).
Why the study?
Are common genetic variants associated with circulating levels of very long-chain saturated fatty acids in subjects of European ancestry?
Population
10,129 subjects of European ancestry from seven population-based cohorts
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports genetic links to very long-chain fatty acid levels; leaves open causal roles in cardiometabolic disease.
Study Design
Type
Observational (n=10,129)
Multicenter
Yes
Structured PICO
Are common genetic variants associated with circulating levels of very long-chain saturated fatty acids in subjects of European ancestry?
P
Population
10,129 subjects of European ancestry from seven population-based cohorts.
E
Exposure
Genome-wide association study (GWAS) of common genetic variants
O
Outcome
Plasma phospholipid/erythrocyte levels of three very long-chain saturated fatty acids (VLSFAs: arachidic acid, behenic acid, and lignoceric acid)surrogate
Main Result
p-value: p=2.65 × 10(-40)
Common genetic variants in the SPTLC3 and CERS4 genes are associated with circulating levels of very long-chain saturated fatty acids, suggesting an inter-relationship with sphingolipid synthesis.
Cite This Study
Lemaître et al. (2014) reported an observational. Common genetic variation (SPTLC3 and CERS4 variants) was evaluated on Plasma phospholipid/erythrocyte levels of three very long-chain saturated fatty acids (VLSFAs) (p=2.65 × 10(-40)). Common genetic variants in SPTLC3 (rs680379) and CERS4 (rs2100944) were significantly associated with circulating levels of arachidic acid (P=5.81×10^-13 and P=2.65×10^-40, respectively).