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Experimental study demonstrates the synthesis of isomeric platinum (IV) complexes, suggesting new avenues for developing platinum-based antitumor drugs.
A series of isomeric 1, 2-diaminocyclohexane platinum (IV) complexes of the type DACH-PtIV-trans(X)2 cis(Y) (where DACH = trans-R,R-, trans-S,S- or cis-1,2-diaminocyclohexane, X = chloro, bromo, acetato, or trifluoroacetato, and Y = dichloro, dibromo, 1,1-cyclobutanedicarboxylato, tartronato, ketomalonato, or methylmalonato) has been synthesized. The isomeric DACH-PtIV-trans(X)2 cis(Y) complexes were prepared by first oxidizing the corresponding DACH-dihaloplatinum(II) or DACH-dicarboxylato-platinum(II) [DACH-PtIIY] with hydrogen peroxide to DACH-PtIV-trans(OH)2Y, and then replacing the axial hydroxo groups with chloro, bromo, or monocarboxylato ligands. These complexes were characterized by elemental analysis, and infrared and nuclear magnetic resonance (195Pt{1H}) spectroscopic techniques.
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Al-Baker et al. (1994) studied this question.
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