Key result
Ethanol ingestion induced myocardial ischemia in a patient with vasospastic angina, with the time course and severity coinciding with abnormally high blood acetaldehyde levels.
Why the study?
Does ethanol ingestion induce myocardial ischemia in a patient with vasospastic angina?
Case Report (n=1)
Does ethanol ingestion induce myocardial ischemia in a patient with vasospastic angina?
High blood acetaldehyde levels following ethanol ingestion may trigger coronary vasospasm and myocardial ischemia in susceptible patients.
High acetaldehyde after ethanol may trigger ischemia in vasospastic angina; hypothesis-generating for avoidance counseling and mechanistic studies.
A patient with vasospastic angina who developed myocardial ischemia following ethanol ingestion but not after exercise was described. Myocardial ischemia was evidenced by electrocardiograms (ECGs) and thallium-201 scintigrams. The blood acetaldehyde level after ethanol ingestion was abnormally high. The time course and severity of myocardial ischemia coincided with those of the blood ethanol and acetaldehyde level. Coronary arteriography showed ergonovine maleate-induced coronary vasospasm at the left anterior descending coronary artery. ECG changes similar to those induced by ethanol ingestion were observed at the same time. These findings suggest that the high blood acetaldehyde level might be responsible for the development of coronary vasospasm and myocardial ischemia in this patient.
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Ando et al. (1993) conducted a case report in vasospastic angina (n=1). Ethanol ingestion was evaluated on myocardial ischemia. Ethanol ingestion induced myocardial ischemia in a patient with vasospastic angina, with the time course and severity coinciding with abnormally high blood acetaldehyde levels.
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