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September 1, 1974CirculationOpen Access

Role of Autonomic Nervous System in the Pathogenesis of Prinzmetal's Variant Form of Angina

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Why the study?

Do autonomic nervous system drugs induce or suppress attacks in patients with Prinzmetal's variant angina?

Population

10 patients with Prinzmetal's variant form of angina, including 3 having recurrent spontaneous attacks at…

Design

Case_series

Authors

HYHirofumi YasueGeneral CardiologyMTMasato TouyamaOkinawa Prefectural Chubu HospitalMSM ShimamotoKagoshima University

Discussion

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Implication

Suggests autonomic modulation in variant angina; leaves open therapeutic relevance pending controlled trials.

Structured PICO

Do autonomic nervous system drugs induce or suppress attacks in patients with Prinzmetal's variant angina?

P
Population
10 patients with Prinzmetal's variant form of angina, including 3 having recurrent spontaneous attacks at the time of examination.
I
Intervention
Subcutaneous methacholine (10 mg), atropine (0.7 mg), and epinephrine (0.7 mg); intravenous isoproterenol (20-25 µg/min); oral atropine (0.6-1.2 mg), propranolol (30-90 mg), and phenoxybenzamine (10 mg); Master's triple two-step test; selective coronary arteriography.
O
Outcome
Induction or suppression of angina attackspatient reported

Enhanced parasympathetic activity at rest may initiate Prinzmetal's variant angina attacks by stimulating sympathetic nerves and activating alpha receptors to induce coronary spasm.

Cite This Study

Yasue et al. (1974) studied this question.

synapsesocial.com/papers/6a1d44c97328fa9a742f3d49https://doi.org/10.1161/01.cir.50.3.534
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prinzmetal’s Variant Angina1976 · 227 citations
  2. 2Methacholine provocation of prinzmetal's variant angina pectoris: A revised perspective1982 · 14 citations
  3. 3Prinzmetal's variant form of angina pectoris. Re-evaluation of mechanisms.1975 · 189 citations
  4. 4PRINZMETAL'S VARIANT ANGINA1981 · 2 citations
  5. 5Left ventricular performance and related haemodynamic changes in Prinzmetal's variant angina pectoris1971 · 128 citations