Key result
Abrupt discontinuation of aspirin and statin in a patient with previous cardiovascular disease led to acute innominate artery occlusion, which spontaneously recanalized after early re-initiation of the medications.
Why the study?
Does abrupt discontinuation of aspirin and statin increase the risk of ischaemic stroke in patients with previous cardiovascular disease?
Case Report (n=1)
Does abrupt discontinuation of aspirin and statin increase the risk of ischaemic stroke in patients with previous cardiovascular disease?
Abrupt discontinuation of aspirin and statin in high-risk patients can lead to severe thromboembolic events, highlighting the critical importance of medication adherence for secondary prevention.
Answers are grounded in this paper and cite their sources.
Supports caution against abrupt aspirin/statin cessation in prior CVD; single case leaves open prospective stroke-risk confirmation.
Statin and antiplatelet drugs are widely used for prevention of ischaemic stroke and other cardiovascular diseases in high-risk patients. We report a rare case of a 49-year old man with a history of myocardial infarction and hyperlipidaemia who suffered an acute occlusion of his innominate artery (IA) accompanied by subclavian steal syndrome and cerebral infarction, on day seven after abrupt cessation of aspirin and statin, as confirmed by magnetic resonance and computed tomographic angiography of head and neck, and colour-coded Duplex ultrasonography (CCDU). Aspirin and atorvastatin were immediately re-started on admission. Spontaneous recanalization of IA was shown on repeat CCDU and digital subtraction angiography on day 10 after stroke onset. This case serves as a reminder that abrupt discontinuation of both aspirin and statin in patients with previous history of cardiovascular disease may increase the risk of ischaemic stroke.
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Lee et al. (2014) conducted a case report in Acute innominate artery thromboembolic occlusion (n=1). Abrupt discontinuation of aspirin and statin was evaluated on Innominate artery occlusion and subsequent recanalization. Abrupt discontinuation of aspirin and statin in a patient with previous cardiovascular disease led to acute innominate artery occlusion, which spontaneously recanalized after early re-initiation of the medications.
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