MyoD1 protein expression provides strong evidence supporting the skeletal muscle nature of alveolar soft part sarcoma.
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MyoD1 expression in this alveolar soft part sarcoma case supports myogenic differentiation; leaves open diagnostic utility pending larger series.
A typical case of alveolar soft part sarcoma was found to express in a strong and widespread fashion the marker MyoD1 protein. This nuclear phosphoprotein is the product of a regulatory gene that controls the commitment of a cell to myogenic lineage; it therefore provides strong and perhaps definitive evidence in support of the skeletal muscle nature of this enigmatic neoplasm.
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Rosaí et al. (1991) studied this question.
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