Why the study?
Does the immunohistochemical profile of myogenin and MyoD1 support a skeletal muscle lineage in alveolar soft part sarcoma?
Population
n=19 cases of formalin-fixed, paraffin-embedded alveolar soft part sarcoma
Design
Case_series
Authors
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IHC profile argues against myogenic origin in alveolar soft part sarcoma; leaves open alternative histogenesis for validation.
Does the immunohistochemical profile of myogenin and MyoD1 support a skeletal muscle lineage in alveolar soft part sarcoma?
The lack of specific nuclear immunostaining with myogenin and MyoD1, along with negative desmin and muscle-specific actin, provides evidence against a myogenic origin for alveolar soft part sarcoma.
Gómez et al. (1999) studied this question.
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