Key result
Single molecule biophysical studies are beginning to reveal the molecular mechanisms by which the intracellular cargo transporter myosin V moves processively along actin filaments.
This review highlights emerging biophysical details regarding the walking mechanism of the intracellular cargo transporter myosin V.
Emerging myosin V details may guide motor protein research; leaves open clinical translation in cardiovascular mechanobiology.
Motor proteins of the myosin, kinesin and dynein families transport vesicles and other cargo along tracks of actin filaments or microtubules through the cytoplasm of cells. The mechanism by which myosin V, a motor involved in several types of intracellular transport, moves processively along actin filaments, has recently been the subject of many single molecule biophysical studies. Details of the molecular mechanisms by which this molecular motor operates are starting to emerge.
No takes yet. Share an insight, caveat, or question.
Schmitz et al. (2006) reported a review. Myosin V was evaluated. Single molecule biophysical studies are beginning to reveal the molecular mechanisms by which the intracellular cargo transporter myosin V moves processively along actin filaments.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: