Chondromyxoid fibroma in a 24-year-old female: A case report highlighting its rarity, diagnostic challenges, and importance of surgical management

Chondromyxoid fibroma (CMF) is an uncommon benign bone tumor, involving less than 1% of all bone neoplasms and is slightly more predominant in males. This case report describes a 24-year-old female patient who presented with a painless, progressively enlarging swelling on the left upper leg for six years. Radiographic imaging revealed a lytic lesion with a soap bubble appearance, well-defined margins, and endosteal scalloping in the proximal tibia. Histological analysis confirmed CMF, characterized by chondromyxoid lobules with fibroblastic proliferation and no evidence of malignancy. Surgical excision of the 6 x 8 cm tumor, involving the fibula and tibia, was performed without complications. This case highlights the rarity of CMF in females, its diagnostic challenges, and the efficacy of surgical management, emphasizing clinical, radiographic, and histopathological features.