The role of microcompartmentation in the regulation of glutamate metabolism by rat kidney mitochondria.

This is the authors' abstract. We don't add key points for this paper.

Further insights into the augmented rate of glutamate deamination in metabolic acidosis have been obtained from experiments with renal cortical mitochondria from control and acidotic rats.Mitochondria were incubated with varying concentrations of glutamine to generate glutamate at different rates.Glutamate dehydrogenase flux was found to be proportional to matrix glutamate but the proportionality was different in acidosis compared to control.Although the V,, was similar, the K,,, for glutamate decreased in acidosis to one-fourth the control value.