Post-Herpetic Erythema Multiforme Prevented with Prophylactic Oral Acyclovir

Brief Reports1 May 1985Post-Herpetic Erythema Multiforme Prevented with Prophylactic Oral AcyclovirJON A. GREEN, M.D., Ph.D., SPOTSWOOD L. SPRUANCE, M.D., GAY WENERSTROM, R.N., MICHAEL W. PIEPKORN, M.D., Ph.D.JON A. GREEN, M.D., Ph.D., SPOTSWOOD L. SPRUANCE, M.D., GAY WENERSTROM, R.N., MICHAEL W. PIEPKORN, M.D., Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-632 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecurrent herpes simplex virus infection predisposes to the development of erythema multiforme in some persons (1) and can lead to a pattern of recurrent erythema multiforme and disabling morbidity. Recent reports of the safety and efficacy of oral acyclovir for the prophylaxis of recurrent herpes virus infections (2-4) suggest a similar application for the prevention of herpes virusrelated erythema multiforme.A 26-year-old white man, a professional housepainter, had recurrent labial herpes virus infections for 12 years with a stable pattern of three to five episodes a year. At age 24 he began having accelerated recurrences at monthly or bimonthly intervals....References1. ORTONHUFFTONNESSENWESTON PJMW. Detection of a herpes simplex viral antigen in skin lesions of erythema multiforme. Ann Intern Med. 1984;101:48-50. LinkGoogle Scholar2. WADENEWTONFLOURNOYMEYERS JBNJ. Oral acyclovir for prevention of herpes simplex virus reactivation after marrow transplantation. Ann Intern Med. 1984;100:823-8. LinkGoogle Scholar3. DOUGLASCRITCHLOWBENEDETTI JCJ. A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N Engl J Med. 1984;310:1551-6. CrossrefMedlineGoogle Scholar4. STRAUSSTABIFFSEIDLIN SHM. Suppression of frequently recurring genital herpes: a placebo-controlled double-blind trial of oral acyclovir. N Engl J Med. 1984;310:1545-50. CrossrefMedlineGoogle Scholar5. SPRUANCEOVERALLKERNKRUEGERPLIAMMILLER SJEGVW. The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. N Engl J Med. 1977;297:69-75. CrossrefMedlineGoogle Scholar6. SPRUANCE S. Pathogenesis of herpes simplex labialis: excretion of virus in the oral cavity. J Clin Microbiol. 1984;19:675-9. CrossrefMedlineGoogle Scholar7. KENNEDYLEIGHRIDGWAYWANSBROUGH-JONESBRIGDEN CIHMD. Treatment of erythema multiforme secondary to herpes simplex by prophylactic topical acyclovir. Br Med J. 1981;283:1360-1. CrossrefMedlineGoogle Scholar8. BACIGALUPOFRASSONIVAN LINT AFM. Acyclovir for the treatment of severe aplastic anemia [Letter]. N Engl J Med. 1984;310:1606-7. CrossrefMedlineGoogle Scholar9. RESNICKSCHLEIDER-KUSHNERHORWITZFROST LNSP. Remission of tumor-stage mycosis fungoides following intravenously administered acyclovir. JAMA. 1984;251:1571-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Utah School of Medicine Salt Lake City, Utah. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHerpes Virus Infections Other than Cytomegalovirus in the Recipients of Hematopoietic Stem Cell TransplantationAntiviral AgentsEritema multiformeHerpes Simplex Virus InfectionsHerpes Simplex VirusAntiviral AgentsHerpes Simplex VirusAntiviral AgentsÉrythème polymorpheEritema polimorfoErythema multiforme and related disordersPediatric oral medicineAcyclovir Cream for Treatment of Herpes Simplex Labialis: Results of Two Randomized, Double-Blind, Vehicle-Controlled, Multicenter Clinical TrialsVesiculobullous diseases of the oral cavityInfectious and tropical diseases affecting the human mouthLong-term Oral Acyclovir TherapyNew Aspects of Oral Viral DiseasesA double-blind, placebo-controlled trial of continuous acyclovir therapy in recurrent erythema multiformeAre viruses associated with aphthae and oral vesiculoerosive disorders?Prophylactic chemotherapy with acyclovir for recurrent herpes simplex labialisSystemic Antivirals in Herpesvirus InfectionsErythema multiforme: a literature review and case reportVery low dose acyclovir can be effective as prophylasix for post-herpetic erythema multiformeExogenous triggersErythema multiformeAntiviral therapyTreatment of Herpes Simplex LabialisAcyclovir for recurrent erythema multiforme caused by herpes simplexTreatment of Herpes Simplex Virus InfectionsSuccessful use of oral acyclovir to prevent herpes simplex-associated erythema multiformeDiseases of the mucous membranes in childrenAcyclovir prophylaxis for herpes simplex virus infectionManagement of oral and genital herpes simplex virus infections: Diagnosis and treatmentOral acyclovir for the prevention of herpes-associated erythema multiformeInfections with Herpes Simplex VirusesDermatologic Problems in the Intensive Care Unit: Part IChemotherapy of herpesvirus infections: Present successes and future hopes 1 May 1985Volume 102, Issue 5Page: 632-633KeywordsErythemaHerpes simplexInfectious diseasesMorbidityProphylaxisSafetySalts Issue Published: 1 May 1985 PDF DownloadLoading ...