Surface Modification of Tobacco Mosaic Virus with “Click” Chemistry

This is the authors' abstract. We don't add key points for this paper.

Click conjugation of tobacco mosaic virus: As a prototype of “click” chemistry, the CuI catalyzed azide-alkyne cycloaddition reaction in combination with diazonium-coupling proved to be an efficient, versatile, and benign method to conjugate a wide range of compounds to phenolic groups of protein tyrosines. In particular, plant virus tobacco mosaic virus was chosen as a multivalent protein scaffold to demonstrate this bioconjugation strategy.