Synthesis, Characterization, and Cellular Uptake of a Glycylglycine Chelate of Magnesium

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High Resolution Image Download MS PowerPoint Slide Human chronic latent magnesium deficiency is estimated to impact a substantive portion of the world’s population. A number of magnesium compounds have been developed to combat this deficiency; however, none are ideal due to issues of solubility, absorption, side effects (e.g., laxation) and/or formulation. Here, we describe the pH-dependent synthesis, chemical characterization (inductively coupled plasma and thermal analysis, infrared and nuclear magnetic resonance (1D and 2D) spectroscopies, and electrospray mass spectrometry) and in vitro uptake (in a cell model of the large intestine (CaCo-2 cells)) of a magnesium complex of the glycine dimer (HG 2 ). Results demonstrate that the HG 2 ligand assumes a tridentate coordination mode with an N 2 O donor set and an octahedral coordination sphere completed with coordinated waters. The magnesium:HG 2 complex exhibits significant solubility and cellular uptake.