What question did this study set out to answer?

To determine the effects of trans-10,cis-12 conjugated linoleic acid on lipoprotein lipase, lipogenic enzymes, and associated transcription factors in hamster adipose tissue.

May 23, 2006British Journal Of NutritionOpen Access

trans-10,cis-12 Conjugated linoleic acid inhibits lipoprotein lipase but increases the activity of lipogenic enzymes in adipose tissue from hamsters fed an atherogenic diet

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Authors

AZAmaia Zabala‐LetonaBioCruces Health research Institute ICItziar ChurrucaUniversity of the Basque Country AFAlfredo Fernández‐QuintelaUniversity of the Basque Country

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Implication

Controlled animal study reveals trans-10,cis-12 CLA reduces adipose mass via lipoprotein lipase inhibition in hamsters, indicating a key enzymatic pathway in dietary fat reduction.

Key Points

To determine the effects of trans-10,cis-12 conjugated linoleic acid on lipoprotein lipase, lipogenic enzymes, and associated transcription factors in hamster adipose tissue.
Divided 30 male hamsters into three groups receiving an atherogenic diet supplemented with 0, 5, or 10 g trans-10,cis-12 CLA/kg diet for 6 weeks.
Measured body weight, adipose tissue weight, food intake, serum insulin, and the activity of lipoprotein lipase and lipogenic enzymes (ACC, FAS, G6PDH, and ME).
Quantified mRNA expression of LPL, ACC, FAS, SREBP-1a, SREBP-1c, and PPARgamma in adipose tissue using real-time PCR.
CLA supplementation significantly reduced adipose tissue weight, LPL activity, and LPL mRNA expression without altering food intake, total body weight, or serum insulin.
Lipogenic enzyme activities increased following CLA supplementation despite significant down-regulation of ACC and FAS mRNA levels.
Gene expression of the transcriptional regulators SREBP-1a, SREBP-1c, and PPARgamma decreased significantly in adipose tissue.

Cite This Study

Zabala‐Letona et al. (2006) studied this question.

synapsesocial.com/papers/6a9a73cb861e0cddfb4e1fbd https://doi.org/10.1079/bjn20061774

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Implication

Controlled animal study reveals trans-10,cis-12 CLA reduces adipose mass via lipoprotein lipase inhibition in hamsters, indicating a key enzymatic pathway in dietary fat reduction.

trans-10,cis-12 Conjugated linoleic acid inhibits lipoprotein lipase but increases the activity of lipogenic enzymes in adipose tissue from hamsters fed an atherogenic diet

Discussion

Member takes

Implication

Key Points

Cite This Study

trans-10,cis-12 Conjugated linoleic acid inhibits lipoprotein lipase but increases the activity of lipogenic enzymes in adipose tissue from hamsters fed an atherogenic diet

Discussion

Member takes

Implication

Key Points

Cite This Study

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