Key result
The Heart Rate Observation (HeRO) score was significantly higher in septic preterm neonates than non-septic neonates on day 1 (median 2 vs 1; P<0.001), yielding 92.75% sensitivity at a >1 cutoff.
Why the study?
Preterm neonates are at high risk for sepsis, and early detection prior to clinical deterioration could allow earlier treatment to improve morbidity and outcomes.
Does the Heart Rate Observation (HeRO) score detect neonatal sepsis in preterm neonates?
Observational (n=170)
Does the Heart Rate Observation (HeRO) score detect neonatal sepsis in preterm neonates?
p-value: p=<0.001
The HeRO score demonstrates high sensitivity and specificity for the early detection of sepsis in preterm neonates.
May support earlier sepsis detection in NICU neonates; hypothesis-generating and requires prospective validation before practice change.
Background: Neonates admitted to neonatal intensive care units (NICU) are at an increased risk to develop sepsis, especially preterm neonates because of their immature immune systems. Early detection of sepsis, before pronounced clinical deterioration, would allow earlier administration of supportive treatments and antibiotics this will improve morbidity and lead to favorable outcomes.Objective: The aim of this study was to determine the effectiveness of HeRO score to detect neonatal sepsis in preterm neonatesMethods: This prospective observational study included 170 preterm infants. All studied neonates were subjected to HeRO scores initially and throughout hospital stay. Confirmation of neonatal sepsis was done by withdrawal of positive C-reactive protein (CRP) and positive blood culture.Results: The studied neonates were divided into initial septic group and non-septic neonates; HeRO score showed statistically significant increase in septic patients than non-septic (median (IQR) 2 (2-3) vs. 1 (0-1) respectively for day 1 of admission (p <0.001) and 2 (1-2) vs 0 (0-1) on day 4 of admission (p <0.001) with a cut off value of > 1 in both day 1 and 4 with sensitivity and specificity 92.75% & 98.02% for day 1 and 65.22 % and 85.15% in day 4 respectively. Conclusion: Heart Rate Observation (HeRO) Score can be used for early detection of neonatal sepsis in preterm neonates.
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Ibrahim et al. (2022) conducted an observational in Neonatal sepsis (n=170). Heart Rate Observation (HeRO) Score vs. Non-septic neonates was evaluated on Neonatal sepsis (p=<0.001). The Heart Rate Observation (HeRO) score was significantly higher in septic preterm neonates than non-septic neonates on day 1 (median 2 vs 1; P<0.001), yielding 92.75% sensitivity at a >1 cutoff.
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