Key result
High IL-6 blood levels upon admission were significantly correlated with depressed heart rate variability, including low-frequency (r = -0.76, P<0.01) and high-frequency power (r = -0.53, P<0.01).
Observational (n=45)
No
Effect estimate: r = -0.76
p-value: p=<0.01
Depressed heart rate variability in septic patients correlates with hypercytokinemia (IL-6) and blood pressure decline, linking autonomic dysfunction with inflammatory severity.
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May link inflammation to autonomic dysfunction in shock; hypothesis-generating and should not yet change practice.
Tateishi et al. (2007) conducted an observational in Sepsis (n=45). IL-6 blood level was evaluated on Correlation between IL-6 blood level and low-frequency power (LF) of heart rate variability (r = -0.76, p=<0.01). High IL-6 blood levels upon admission were significantly correlated with depressed heart rate variability, including low-frequency (r = -0.76, P<0.01) and high-frequency power (r = -0.53, P<0.01).
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