Key result
Supplementing succinate in drinking water lowered fat mass and improved glucose tolerance and energy expenditure in high-fat diet induced obese mice.
Why the study?
Obesity is rising dramatically and leads to adipose tissue expansion and metabolic dysfunction involved in multiple chronic diseases, prompting evaluation of the role of succinate in obesity intervention.
Does succinate supplementation reduce lipid deposition and improve metabolic function in high-fat diet induced obese mice?
Does succinate supplementation reduce lipid deposition and improve metabolic function in high-fat diet induced obese mice?
Succinate supplementation improves metabolic health and reduces lipid deposition in a preclinical model of diet-induced obesity.
May warrant succinate investigation in human obesity trials; extends preclinical data but leaves translation open.
The number of obese people worldwide is rising dramatically, with 51% of the global population expected to be obese or overweight by 2035. And it is usually involved in a variety of chronic diseases, including diabetes, hypertension, cardiovascular and cerebrovascular diseases. In the process of obesity, adipose tissue expands indefinitely, which induces metabolic dysfunction. Here, we confirm the role of succinate in the intervention of obesity. Through adding succinate to drinking water, high-fat diet induced obese mice were associated with the lower fat mass, and improved glucose tolerance and energy expenditure. These metabolic changes are accompanied by increased expression of lipolysis genes and decreased lipogenesis genes, especially in subcutaneous adipose tissue. In summary, supplement of succinate improves lipid deposition and metabolic health in obese mice.
No takes yet. Share an insight, caveat, or question.
Ji et al. (2023) studied Obesity. Succinate was evaluated on fat mass, glucose tolerance, and energy expenditure. Supplementing succinate in drinking water lowered fat mass and improved glucose tolerance and energy expenditure in high-fat diet induced obese mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: