Key result
A 29-year-old male developed severe dilated cardiomyopathy with an ejection fraction of 5%, focal segmental glomerulosclerosis, and Bell's palsy following a Coxsackievirus infection.
Case Report (n=1)
This case highlights a rare presentation of Coxsackievirus infection leading to severe dilated cardiomyopathy, focal segmental glomerulosclerosis, and Bell's palsy.
May prompt viral serology in young adults with fulminant HF plus multi-organ disease; hypothesis-generating for Coxsackievirus cardiomyopathy-FSGS links.
Dilated cardiomyopathy (DCM) is a severe myocardial disease with diversified etiologies. Coxsackievirus serotype B (CV-B) is a known cause of infectious myocarditis that leads to DCM. The pathogenesis of CV-B myocarditis is complex and involves a combination of tissue destruction from viral proliferation and host immune response. Diagnosis is based on clinical findings and the presence of post-infection elevated titers of IgM antibodies to CV-B. Echocardiography is an important imaging modality that plays a key role in diagnosing DCM. Rare complications of coxsackievirus infection may include facial paralysis and chronic kidney disease with nephrotic syndrome. Here we present a rare case of a 29-year-old-male with recent Bell's palsy who presented with new-onset heart failure with left ventricular ejection fraction of 5% and focal segmental glomerulosclerosis nephrotic syndrome in the setting of elevated antibodies to CV-B.
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Ahmed et al. (2022) conducted a case report in Dilated cardiomyopathy, focal segmental glomerulosclerosis, and Bell's palsy (n=1). Coxsackievirus infection was evaluated. A 29-year-old male developed severe dilated cardiomyopathy with an ejection fraction of 5%, focal segmental glomerulosclerosis, and Bell's palsy following a Coxsackievirus infection.
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