What question did this study set out to answer?

To determine how elevated beta-catenin affects the core circadian clock protein PER2 and regulates clock-controlled gene expression in intestinal epithelial cells.

December 24, 2008The Journal of Biochemistry

-Catenin Induces -TrCP-Mediated PER2 Degradation Altering Circadian Clock Gene Expression in Intestinal Mucosa of ApcMin/+ Mice

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Authors

XYXiaoming YangUniversity of South Carolina PWPatricia A. WoodUniversity of South Carolina CAChristine AnsellDorn Research Institute

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Implication

Animal study reveals beta-catenin degrades PER2 via beta-TrCP in ApcMin/+ mouse intestinal mucosa, suggesting circadian disruption drives intestinal neoplastic transformation.

Key Points

To determine how elevated beta-catenin affects the core circadian clock protein PER2 and regulates clock-controlled gene expression in intestinal epithelial cells.
Examined the molecular pathway linking beta-catenin, beta-TrCP (an F-box protein of SCF ubiquitin E3 ligase), and PER2 protein stability.
Profiled the circadian expression patterns of core clock genes (Per1, Per2) and clock-controlled cell cycle genes (Dbp, Wee1) in intestinal mucosa of ApcMin/+ mice.
Increased beta-catenin induces beta-TrCP expression, triggering the targeted degradation and destabilization of PER2 protein.
Depletion of PER2 protein in ApcMin/+ mouse intestinal mucosa is accompanied by disrupted circadian rhythms of Per1, Per2, Dbp, and Wee1 expression.

Cite This Study

Yang et al. (2008) studied this question.

synapsesocial.com/papers/6a9a76ccd7a9d2ca6590acd6 https://doi.org/10.1093/jb/mvn167

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Implication

Animal study reveals beta-catenin degrades PER2 via beta-TrCP in ApcMin/+ mouse intestinal mucosa, suggesting circadian disruption drives intestinal neoplastic transformation.

-Catenin Induces -TrCP-Mediated PER2 Degradation Altering Circadian Clock Gene Expression in Intestinal Mucosa of ApcMin/+ Mice

Discussion

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Implication

Key Points

Cite This Study

-Catenin Induces -TrCP-Mediated PER2 Degradation Altering Circadian Clock Gene Expression in Intestinal Mucosa of ApcMin/+ Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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