Answers are grounded in this paper and cite their sources.
The DNA cleavage properties of two cationic manganese porphyrins possessing different peripheral substituents were compared. The identical nature of the strand scission patterns of the porphyrins on a 139 base pair restriction fragment of pBR-322 DNA, along with other evidence, suggests that the porphyrin is end-on bound via the minor groove in a melted or partially melted region of DNA. This unusual binding mode underscores the potential of outisde binding cationic metalloporphyrins as probes for low melting regions of DNA
No takes yet. Share an insight, caveat, or question.
Raner et al. (1988) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: