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June 1, 2025JAAOS Global Research and ReviewsOpen Access

Utility of Revised Risk Analysis Index as a Predictor of Mortality and Morbidity in Orthopaedic Trauma

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Key result

The RAI-Rev demonstrated significantly superior predictive discrimination compared with the mFI-5 for predicting 30-day mortality (C-statistic 0.84 vs 0.67, P < 0.001) in orthopaedic trauma patients.

Why the study?

The study was conducted to determine the applicability of the Revised Risk Analysis Index in orthopaedic trauma and compare its predictive discrimination to the 5-Item Modified Frailty Index for 30-day postoperative outcomes.

Does the RAI-Rev provide superior predictive discrimination compared to the mFI-5 for 30-day postoperative outcomes in orthopaedic trauma patients?

Population

206,352 patients aged 18 or older undergoing surgery for orthopaedic fractures

Comparison

Revised Risk Analysis Index (RAI-Rev) vs 5-Item Modified Frailty Index (mFI-5)

Design

Retrospective cohort study

Follow-up

30 days

Authors

CSChirag SoniIndiana University HealthVKVictor KoltenyukMontefiore Medical CenterNGNithin GuptaUniversity of North Carolina at Chapel Hill

Discussion

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Implication

RAI-Rev may aid risk stratification over mFI-5 for mortality and complications in trauma; leaves open prospective validation before clinical adoption.

Study Design

Type

Cohort (n=206,352)

Multicenter

Yes

Structured PICO

Does the RAI-Rev provide superior predictive discrimination compared to the mFI-5 for 30-day postoperative outcomes in orthopaedic trauma patients?

P
Population
206,352 adults aged 18 and older undergoing surgical treatment for orthopaedic trauma fractures, evaluated for 30-day postoperative outcomes.
E
Exposure
Risk stratification using the Revised Risk Analysis Index (RAI-Rev)
C
Comparator
Risk stratification using the 5-Item Modified Frailty Index (mFI-5)
O
Outcome
30-day postoperative mortalityhard clinical

Main Result

Absolute Event Rate: 0.84% vs 0.67%

p-value: p=<0.001

The RAI-Rev demonstrates superior predictive discrimination for 30-day mortality, major complications, and readmission compared to the mFI-5 in orthopaedic trauma patients.

Limitations

  • Retrospective nature of the study limits the determination of causation and the ability to control for all confounding variables
  • Reliance on accurate coding and data input within the NSQIP database
  • Exclusion of preoperative cognitive status from frailty measures in the database
  • Lack of granularity regarding nutritional status, with weight loss and poor appetite recorded under the same variable
  • Lack of granularity limited the analysis of polytraumatized patients
  • Retrospective nature of the study
  • Reliance on accurate coding and data input
  • Exclusion of preoperative cognitive status from frailty measures
  • Lack of granularity regarding nutritional status (weight loss and poor appetite recorded under same variable)
  • Lack of granularity limiting analysis of polytraumatized patients

Cite This Study

Soni et al. (2025) conducted a cohort in Orthopaedic trauma (n=206,352). Revised Risk Analysis Index (RAI-Rev) vs. 5-Item Modified Frailty Index (mFI-5) was evaluated on Predictive discrimination (C-statistic) for 30-day mortality (p=<0.001). The RAI-Rev demonstrated significantly superior predictive discrimination compared with the mFI-5 for predicting 30-day mortality (C-statistic 0.84 vs 0.67, P < 0.001) in orthopaedic trauma patients.

synapsesocial.com/papers/6a9a79e7e2b1f63cbde4497chttps://doi.org/10.5435/jaaosglobal-d-25-00086
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Surgical Risk Factors, Morbidity, and Mortality in Elderly Patients2006 · 1,079 citations
  2. 2Frailty Is More Predictive of Mortality than Age in Patients With Hip Fractures2024 · 23 citations
  3. 3Predictors of mortality in geriatric trauma patients2014 · 337 citations
  4. 4Impact of Frailty and Malnutrition on Outcomes After Surgical Fixation of Lower Extremity Fractures in Young Patients2020 · 26 citations
  5. 5Recalibration and External Validation of the Risk Analysis Index2019 · 246 citations