Key result
In an in-vitro model, a stenotic aortic valve resulted in a small amount of retrograde coronary flow (<1% of total coronary flow) during the initial phase of systole.
Why the study?
Does a stenotic aortic valve alter coronary flow dynamics compared to a normal aortic valve in an in-vitro pulse duplicating system?
Population
In-vitro pulse duplicating system simulating coronary flow, utilizing an acrylic mold of a calf aortic root…
Comparison
Human stenotic valve in the aortic position vs Normal porcine valves in the aortic and mitral…
Design
Preclinical
Authors
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No immediate change to aortic stenosis management; leaves open in-vivo relevance of early systolic retrograde flow.
Does a stenotic aortic valve alter coronary flow dynamics compared to a normal aortic valve in an in-vitro pulse duplicating system?
In an in-vitro model, aortic stenosis leads to a small amount of retrograde coronary flow during early systole, likely due to compression of the coronary artery from elevated intramural pressure.
Sabbah et al. (1982) studied Aortic valvular stenosis. Stenotic aortic valve vs. Normal aortic valve was evaluated on Retrograde coronary flow. In an in-vitro model, a stenotic aortic valve resulted in a small amount of retrograde coronary flow (<1% of total coronary flow) during the initial phase of systole.
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