Key result
Electron microscopy of the M-2 cell line derived from a patient with chronic myelogenous leukemia revealed herpes-like particles in approximately 5% of the cells.
Suggests possible viral involvement in CML; hypothesis-generating and should not yet change practice or guide research priorities.
Ultrastructural characteristics of one cell type contained in the M-2 line derived from the buffy coat of a patient with chronic myelogenous leukemia are described. Herpes-like particles found in approximately 5% of this cell type are compared with particles described from Burkitt lymphoma lines and the RPMI 64–10 line derived from a patient with acute myelogenous leukemia. The significance of nuclear and mitochondrial changes accompanying viral infection is discussed. Virus associated with the M-2 line is morphologically indistinguishable from that of several Burkitt lymphoma and RPMI 64–10 lines.
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Zeve et al. (1966) studied Chronic Myelogenous Leukemia (n=1). Electron microscopy of M-2 cell line vs. Burkitt lymphoma lines and RPMI 64-10 line was evaluated on Detection of herpes-like particles. Electron microscopy of the M-2 cell line derived from a patient with chronic myelogenous leukemia revealed herpes-like particles in approximately 5% of the cells.
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