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In vitro study demonstrates replication dynamics of herpes simplex virus in human Burkitt lymphoma cell lines, indicating susceptibility of malignant lymphoid cells to productive infection.
The growth of herpes simplex virus has been studied in two lymphoid cell lines derived from patients with malignant lymphoma of the Burkitt type. Cultures were examined by light and electron microscopy at selected intervals after virus infection, and ultrastructural changes were correlated with the virus growth curves. The initial penetration of herpes simplex virus was detected. In cultures inoculated with a high multiplicity of virus, nucleolar and chromatin alterations were observed after 5 hours, and immature virus capsids developed in the nucleus after 10 hours. Mature cytoplasmic or extracellular virions accumulated in large numbers after 15 hours. Disruption of nuclear membranes was prominent in late infection. Intranuclear inclusions of the Cowdry Type A were observed by light microscopy in appropriately fixed sections of the herpes-infected lymphoma cells, but could not be discerned in companion cell smears stained with Giemsa. A recticular network associated with the endoplasmic reticulum or annulate lamellae in both control and infected lymphoma cells is described.
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Bedoya et al. (1968) studied this question.
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