Electrochemical Detection of Serotonin Using Conductive Diamond Electrodes

The electrochemical detection of serotonin with highly boron-doped diamond thin film electrodes was investigated by use of flow injection analysis (FIA) with amperometric detection. The voltammetric behavior of diamond indicated low background current and a low tendency to adsorb the oxidative products on the electrode surface, in comparison to the glassy carbon electrode. An experimental amperometric detection limit of 10 nM (0.2 pmol) was obtained for the FIA technique, demonstrating that diamond is a stable and sensitive electrode for serotonin determination.