Effect of Serum Bisphenol A and Low T3 on Short-Term Prognosis of Young Patients with Intracerebral Hemorrhage

BackgroundBisphenol A (BPA) is an environmental chemical substance, and the widespread use of plastic products, its hazards can be said to be ubiquitous. We aimed to evaluate the relationship between serum bisphenol A (BPA), biomarkers and recent mortality in pats with young interacerebral hemorrhage (YICH) and different thyroid functions,and the cumulative consumption of plastic products.MethodsUsing a multi-center longitudinal prospective study, the research team recruited 600 YICH patients and divided them into two subgroups according to their thyroid function, of which 320 (53.3%) were in the low T3.Sub-clinical hypothyroidism(SCH) was 280 (46.6%) and control group (n = 600).All patients received serum BPA, and biomarker blood draws.ResultsEach log unit of BPA increased by 0.204 standard deviation unit (P<0.003).BPA(0.91±0.14)vs(0.765±0.13)vs(0.535±0.11)pg/ml,thrombin(1.35±0.18) vs (0.66±0.15) vs (0.66 ±0.15) ng/ml, MMP-9 (104±10 vs (53±8.1)vs(53±8.1) pg/ml,both P＜0.01. Serum BPA is positively correlated with biomarker, 24hDBPCV, and was negatively correlated LT3 and niR-451. Multiple linear regression showed that BPA was an independent risk factor affecting the percentage increase of nDBP (β = 0.286), P <0.01.Mortality rate showed 2 ,15 and 30 days of patients in the LT3 and the SCH of 4.7%vs 2.5%,6.25% vs 3.75%,4.68%vs 2.5%,P<0.01.ConclusionThus, Long-term exposure to BPA levels may be related to the occurrence of YICH, High BPA exposure strongly predicts the risk of ICH in young patients. Activation of NF-κB signaling pathway, secondary thyroid function and ABP changes, together to construct an inflammatory response program, is related to the risk of short-term death. There is a significant difference in recent mortality compared to LT3 vs SCH. Trial registrationThe trial is registered at clinical .gov (www.medresman.