Direct Catalytic Asymmetric Addition of Allylic Cyanides to Aldehydes for Expeditious Access to Enantioenriched Unsaturated δ‐Valerolactones

This is the authors' abstract. We don't add key points for this paper.

A direct catalytic asymmetric γ-addition of allyl cyanide to aldehydes promoted by soft Lewis acid/hard Brønsted base cooperative catalysis is described. The resulting homoallylic alcohols bearing a Z-configured α,β-unsaturated nitrile allow rapid access to enantioenriched δ-valerolactones.