Key result
Preoperative ACE inhibitor (-92%) or beta-blocker (-87%) therapy decreased low-frequency mean arterial pressure variability following anaesthesia compared to untreated patients.
Why the study?
Does preoperative treatment with beta-blockers or ACE inhibitors alter mean arterial pressure and heart rate variability during cardiac surgery with cardiopulmonary bypass in adult patients?
Population
41 adult patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB)
Comparison
Preoperative pharmacological cardiovascular… vs No preoperative pharmacological cardiovascular…
Design
Cohort
Follow-up
before anaesthesia until the end of surgery
Authors
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Hypothesis-generating for perioperative hemodynamic effects; leaves open whether to continue ACE inhibitors or beta-blockers before cardiac surgery.
Observational (n=41)
Does preoperative treatment with beta-blockers or ACE inhibitors alter mean arterial pressure and heart rate variability during cardiac surgery with cardiopulmonary bypass in adult patients?
Preoperative use of ACE inhibitors or beta-blockers alters MAP and HR variability during cardiopulmonary bypass, suggesting both renin-angiotensin and sympathetic systems participate in the genesis of LF variability of MAP.
Neto et al. (2004) conducted an observational in Elective cardiac surgery (n=41). Preoperative beta-blocker or ACE inhibitor therapy vs. No preoperative pharmacological cardiovascular treatment was evaluated on Mean arterial pressure and heart rate variability. Preoperative ACE inhibitor (-92%) or beta-blocker (-87%) therapy decreased low-frequency mean arterial pressure variability following anaesthesia compared to untreated patients.
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