Key result
Black subjects exhibited a decreased area under the curve (P<0.04), peak response (P<0.01), and decay slope (P<0.04) in postocclusive hyperaemic reaction to clobetasol compared to Caucasians.
Why the study?
Does a single application of clobetasol 0.05% induce different cutaneous reactive hyperaemia responses in Black versus Caucasian subjects?
Cross-Sectional (n=14)
Does a single application of clobetasol 0.05% induce different cutaneous reactive hyperaemia responses in Black versus Caucasian subjects?
p-value: p=<0.04
Black subjects exhibit different skin microvascular reactivity to potent topical corticosteroids compared to Caucasians, suggesting intrinsic racial differences in blood vessel reactivity.
May support race-specific topical steroid dosing; hypothesis-generating for microvascular differences and requires prospective validation.
The postocclusive hyperaemic reaction before and after a single 1 h application of a potent corticoid (clobetasol 0.05% in ointment) was recorded by means of laser Doppler velocimetry in order to elucidate different racial responses in skin vasoconstriction. Fourteen young male subjects entered the study (eight Caucasians, six Blacks). Reactive hyperaemia was recorded after 4 min of occlusion of the forearm blood flow. The following parameters of the hyperaemic reaction were investigated: area under the curve response, peak response, rise of blood flow slope to peak and decay of blood flow slope after peak. Different responses were recorded in the Black subjects after the vasoconstrictive stimulus compared to the Caucasians, namely: decreased area under the curve response (P less than 0.04); decreased peak response (P less than 0.01); decreased decay slope after peak blood flow (P less than 0.04). These data are consistent with a different reactivity of blood vessels in black skin and possibly not related to the transcutaneous penetration of the chemical compound.
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Berardesca et al. (1989) reported a cross-sectional. Black race (response to clobetasol 0.05% ointment) vs. Caucasian race was evaluated on Hyperaemic reaction parameters (area under the curve, peak response, decay slope) (p=<0.04). Black subjects exhibited a decreased area under the curve (P<0.04), peak response (P<0.01), and decay slope (P<0.04) in postocclusive hyperaemic reaction to clobetasol compared to Caucasians.
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