What question did this study set out to answer?

Evaluate the real-world effectiveness of a two-dose CoronaVac regimen against severe Covid-19 outcomes—including hospitalization, ICU admission, and death—among older adults.

August 10, 2023VaccineOpen Access

Impact of CoronaVac on Covid-19 outcomes of elderly adults in a large and socially unequal Brazilian city: A target trial emulation study

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Evaluate the real-world effectiveness of a two-dose CoronaVac regimen against severe Covid-19 outcomes—including hospitalization, ICU admission, and death—among older adults.
Conducted a retrospective target trial emulation using registry data from Fortaleza, Brazil, across an eligible cohort of 324,302 adults aged 60 years and older between January and August 2021.
Formed 62,643 1:1 matched pairs of vaccinated and unvaccinated individuals based on age, sex, and neighborhood Human Development Index.
Calculated vaccine effectiveness starting 14 days after the second dose using risk ratios derived from Kaplan-Meier cumulative incidence curves.
Vaccine effectiveness against Covid-19-related death was 82.3% (95% CI, 66.3–93.9) starting 14 days after the second dose.
Vaccine effectiveness reached 68.4% (95% CI, 42.3–86.4) against ICU admission and 55.8% (95% CI, 42.7–68.3) against hospital admission.

Authors

HMHigor S. MonteiroSecretaria da Saúde ANAntonio S. Lima NetoUniversidade Estadual do Ceará RKRebecca KahnCenters for Disease Control and Prevention

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Implication

Target trial emulation demonstrates significant protection against severe Covid-19 outcomes in elderly individuals, indicating the real-world value of CoronaVac.

Cite This Study

Monteiro et al. (2023) studied this question.

synapsesocial.com/papers/6a9a819ea5ca4dc83886868c https://doi.org/10.1016/j.vaccine.2023.07.065

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Implication

Target trial emulation demonstrates significant protection against severe Covid-19 outcomes in elderly individuals, indicating the real-world value of CoronaVac.

Impact of CoronaVac on Covid-19 outcomes of elderly adults in a large and socially unequal Brazilian city: A target trial emulation study

Key Points

Discussion

Implication

Cite This Study

Impact of CoronaVac on Covid-19 outcomes of elderly adults in a large and socially unequal Brazilian city: A target trial emulation study

Key Points

Discussion

Implication

Cite This Study

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