Key result
HIV patients free from cardiovascular risk factors had significantly reduced Global 3D strain (28.5% vs 33.5%, p=0.0002) compared to healthy controls, indicating early subclinical right ventricular dysfunction.
Why the study?
Can advanced 2D and 3D strain echocardiography identify early right ventricular dysfunction in highly selected HIV patients without cardiovascular risk factors compared to healthy controls?
Case-Control (n=16)
No
Can advanced 2D and 3D strain echocardiography identify early right ventricular dysfunction in highly selected HIV patients without cardiovascular risk factors compared to healthy controls?
Absolute Event Rate: 28.5% vs 33.5%
p-value: p=0.0002
Advanced 2D and 3D strain echocardiography can detect early, asymptomatic right ventricular systolic dysfunction in well-controlled HIV patients who are otherwise free of cardiovascular risk factors.
May suggest subclinical RV strain changes in selected HIV patients; leaves open clinical utility pending larger studies.
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Bassareo et al. (2018) conducted a case-control in HIV infection (n=16). HIV infection vs. Healthy matched controls was evaluated on Global 3D strain (p=0.0002). HIV patients free from cardiovascular risk factors had significantly reduced Global 3D strain (28.5% vs 33.5%, p=0.0002) compared to healthy controls, indicating early subclinical right ventricular dysfunction.
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