Key result
LASP-1-positive patients with muscle-invasive bladder cancer demonstrated a decreased survival rate compared with LASP-1-negative patients, and in vitro knockdown of LASP-1 reduced cancer cell invasion and proliferation.
Why the study?
Does LASP-1 expression correlate with bladder cancer malignancy and does its knockdown reduce cancer cell invasion and proliferation?
Observational (n=48)
No
Does LASP-1 expression correlate with bladder cancer malignancy and does its knockdown reduce cancer cell invasion and proliferation?
LASP-1 is highly expressed in invasive bladder cancer and promotes invadopodia formation and cell proliferation, correlating with poor patient prognosis.
LASP-1 positivity may indicate poorer prognosis in muscle-invasive bladder cancer; leaves open therapeutic targeting pending prospective validation.
The LIM and SH3 protein-1 (LASP-1) is a multi-domain protein that is involved in several malignant cancers. The role of LASP-1 in malignant phenotypes including high invasive properties and unrestricted cell proliferation, remain to be elucidated. The present study reported the association of LASP-1 expression with bladder cancer malignancy and its role in cancer cell invasion and proliferation. The immunohistochemical analysis of the expression status of LASP-1 in radical cystectomy specimens from invasive bladder cancer patients revealed that the LASP-1-positive patients demonstrated a decreased survival rate compared with the LASP-1-negative patients. The expression level of LASP-1 was increased in invasive bladder cancer cell lines compared with the non-invasive bladder cancer cell lines. Invasive cancer cells form invadopodia, the filamentous actin-based membrane protrusions that are essential in cancer cell invasion. Knockdown of LASP-1 reduced the ability to form invadopodia, resulting in decreased invasive capacity of the LASP-1 knockdown cells. In addition, knockdown of LASP-1 reduced cell proliferation. These results suggest that LASP-1 is important in invadopodia formation and cell proliferation of bladder cancer cells, promoting the malignant properties and resulting in poor-prognosis.
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Sato et al. (2017) conducted an observational in Muscle invasive bladder cancer (n=48). LASP-1 expression vs. LASP-1 negative was evaluated on Patient survival. LASP-1-positive patients with muscle-invasive bladder cancer demonstrated a decreased survival rate compared with LASP-1-negative patients, and in vitro knockdown of LASP-1 reduced cancer cell invasion and proliferation.
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