Improvement of postoperative pulmonary dysfunction by continuous epidural infusion of a solution combining morphine and bupivacaine.

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Postoperative pulmonary dysfunction (n=21). Intervention: Continuous epidural infusion of morphine and bupivacaine vs. Conventional parenteral analgesia. Primary outcome: PaO2 at 72 hours postoperatively (mmHg) (p=<0.05).

Shinichi Sakura; Toshihiko Nakatani; Yoshihiro Kosaka; Akio Tanaka

doi:10.2199/jjsca.9.294

January 1, 1989THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIAOpen Access

Improvement of postoperative pulmonary dysfunction by continuous epidural infusion of a solution combining morphine and bupivacaine.

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Why the study?

Does continuous epidural infusion of morphine and bupivacaine improve postoperative pulmonary function and analgesia in patients undergoing upper abdominal surgery?

Study Design

Type

RCT (n=21)

Randomization

Randomly assigned

Multicenter

No

Structured PICO

Does continuous epidural infusion of morphine and bupivacaine improve postoperative pulmonary function and analgesia in patients undergoing upper abdominal surgery?

P

Population

21 patients aged 48-74 years (ASA I-II) undergoing upper abdominal surgery, randomized to three analgesic regimens and followed for 72 hours postoperatively.

I

Intervention

Continuous epidural infusion of a combination of morphine and bupivacaine (BM group, n=7).

C

Comparator

Continuous epidural infusion of morphine alone (M group, n=7) or systemic administration of non-narcotic analgesics (C group, n=7).

O

Outcome

Postoperative pulmonary function (PaO2, FRC, FEV1.0) and analgesic effect (Prince Henry pain scale, Visual pain scale) over 72 hours.surrogate

Main Result

Absolute Event Rate: 80.3% vs 69.3%

p-value: p=<0.05

Continuous epidural infusion of a morphine-bupivacaine mixture effectively alleviates pain and improves respiratory function after upper abdominal surgery.

Limitations

Small sample size (N=21)
Single-center study

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Implication

Supports epidural morphine-bupivacaine infusion after upper abdominal surgery; confirms regional analgesia benefits in perioperative RCTs.

Abstract

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Discussion

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Cite This Study

Sakura et al. (1989) conducted an RCT in Postoperative pulmonary dysfunction (n=21). Continuous epidural infusion of morphine and bupivacaine vs. Conventional parenteral analgesia was evaluated on PaO2 at 72 hours postoperatively (mmHg) (p=<0.05).

synapsesocial.com/papers/6a9a8362a54094e97876c551 https://doi.org/10.2199/jjsca.9.294

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Improvement of postoperative pulmonary dysfunction by continuous epidural infusion of a solution combining morphine and bupivacaine.

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Improvement of postoperative pulmonary dysfunction by continuous epidural infusion of a solution combining morphine and bupivacaine.

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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