Key result
Cancer patients experienced an overall incidence rate of 11.60 per 1000 person-years for arterial thromboembolism and 26.32 per 1000 person-years for venous thromboembolism.
Why the study?
The reported incidence of arterial thromboembolism and venous thromboembolism after cancer varies.
Meta-Analysis (n=5,059,134)
This large meta-analysis quantifies the incidence of arterial and venous thromboembolism in cancer patients, demonstrating that VTE is more common than ATE and that risk peaks in the initial stage after cancer diagnosis.
Answers are grounded in this paper and cite their sources.
Pooled TE incidence rates benchmark risk by cancer type and time; extends prior estimates and supports targeted prevention trials.
Background and Aims The reported incidence of arterial thromboembolism (ATE) and venous thromboembolism (VTE) after cancer varies. A meta-analysis was performed to define the incidence of thromboembolism (TE) in cancer patients. Methods Articles were searched in PubMed and Embase from inception to November 1, 2022. Studies reporting the incidence data or data from which incidence could be estimated among patients with cancer and the explicit follow-up duration were included. Results Seventy-four studies involving 5059134 cancer patients were identified. The incidence rate per 1000 person-years was 11.60 (95% CI 7.62-15.58) for ATE, 6.11 (95% CI 3.70-8.53) for myocardial infarction, 9.07 (95% CI 7.48-10.66) for ischemic stroke, 2.11 (95% CI 0.89-3.31) for another ATE, 26.32 (95% CI 24.46-28.18) for VTE, 12.69 (95% CI 11.51-13.87) for deep vein thrombosis, 5.94 (95% CI 5.29-6.59) for pulmonary embolism, and 13.18 (95% CI 9.93-16.42) for another VTE. In addition, the highest incidence of ATE was observed in patients with gastrointestinal cancer, while patients with pancreatic cancer had the highest incidence of VTE. The risk of ATE and VTE increased at the initial stage of cancer, and then declined and became non-significant. Conclusion This meta-analysis provided overall estimates of ATE and VTE incidence in cancer patients, adding an important insight into the trajectory of the development of TE in cancer patients, which could help reduce the risk of TE in cancer patients in the future.
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Deng et al. (2023) conducted a meta-analysis in Cancer (n=5,059,134). Cancer was evaluated on Incidence of Arterial Thromboembolism (ATE) (Incidence Rate 11.60 per 1000 person-years, 95% CI 7.62-15.58). Cancer patients experienced an overall incidence rate of 11.60 per 1000 person-years for arterial thromboembolism and 26.32 per 1000 person-years for venous thromboembolism.
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