What does this research mean for the field?

Elevated homocysteine and triglyceride levels, combined with reduced high-density lipoprotein cholesterol (HDL-C) levels in late pregnancy, are significantly associated with disease severity and adverse neonatal outcomes in hypertensive disorders of pregnancy, and their combined assessment provides strong predictive value. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the correlation between late-pregnancy homocysteine and blood lipid profiles and disease severity in hypertensive disorders of pregnancy, and to determine their predictive value for adverse neonatal outcomes.

September 4, 2026The Journal of Maternal-Fetal & Neonatal MedicineOpen Access

Predictive value of homocysteine and blood lipid levels in late pregnancy for neonatal outcomes in women with hypertensive disorders of pregnancy

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Authors

ZPZhiyu Pan CLC Liu JHJinlan He

Discussion

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Overview

Retrospective study finds late-pregnancy homocysteine and lipid levels predict adverse neonatal outcomes in hypertensive pregnancies, suggesting combined biomarker panels improve risk assessment.

Key Points

To evaluate the correlation between late-pregnancy homocysteine and blood lipid profiles and disease severity in hypertensive disorders of pregnancy, and to determine their predictive value for adverse neonatal outcomes.
Retrospectively analyzed clinical characteristics and laboratory parameters in N=156 patients with hypertensive disorders of pregnancy (61 with gestational hypertension and 95 with preeclampsia).
Measured late-pregnancy levels of homocysteine and lipid panel components, including total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol.
Identified risk factors for adverse neonatal outcomes using logistic regression and subgroup analyses, and evaluated predictive accuracy using receiver operating characteristic (ROC) curves.
Patients with preeclampsia exhibited significantly higher homocysteine, total cholesterol, and triglyceride levels compared to those with gestational hypertension, with all three independently associated with preeclampsia status.
Higher maternal homocysteine and triglyceride levels alongside reduced high-density lipoprotein cholesterol levels in late pregnancy were significantly linked to an elevated risk of adverse neonatal outcomes.
A combined panel of homocysteine, triglycerides, and high-density lipoprotein cholesterol demonstrated superior predictive performance for adverse neonatal outcomes compared with individual biomarkers (area under the ROC curve = 0.874, 95% CI: 0.812–0.922).

Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/6a9a85b05d9e33f25c631102 https://doi.org/10.1080/14767058.2026.2675763

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September 4, 2026The Journal of Maternal-Fetal & Neonatal MedicineOpen Access

Predictive value of homocysteine and blood lipid levels in late pregnancy for neonatal outcomes in women with hypertensive disorders of pregnancy

View Full Paper

Ask AI

Bookmark

Authors

ZPZhiyu Pan CLC Liu JHJinlan He

Discussion

Member takes

Overview

Retrospective study finds late-pregnancy homocysteine and lipid levels predict adverse neonatal outcomes in hypertensive pregnancies, suggesting combined biomarker panels improve risk assessment.

Key Points

To evaluate the correlation between late-pregnancy homocysteine and blood lipid profiles and disease severity in hypertensive disorders of pregnancy, and to determine their predictive value for adverse neonatal outcomes.
Retrospectively analyzed clinical characteristics and laboratory parameters in N=156 patients with hypertensive disorders of pregnancy (61 with gestational hypertension and 95 with preeclampsia).
Measured late-pregnancy levels of homocysteine and lipid panel components, including total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol.
Identified risk factors for adverse neonatal outcomes using logistic regression and subgroup analyses, and evaluated predictive accuracy using receiver operating characteristic (ROC) curves.
Patients with preeclampsia exhibited significantly higher homocysteine, total cholesterol, and triglyceride levels compared to those with gestational hypertension, with all three independently associated with preeclampsia status.
Higher maternal homocysteine and triglyceride levels alongside reduced high-density lipoprotein cholesterol levels in late pregnancy were significantly linked to an elevated risk of adverse neonatal outcomes.
A combined panel of homocysteine, triglycerides, and high-density lipoprotein cholesterol demonstrated superior predictive performance for adverse neonatal outcomes compared with individual biomarkers (area under the ROC curve = 0.874, 95% CI: 0.812–0.922).

Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/6a9a85b05d9e33f25c631102 https://doi.org/10.1080/14767058.2026.2675763

View Full Paper

Ask AI

Bookmark