Omission of an Expected Visual Stimulus Produces a Reproducible, Control-Robust Alteration of Population Geometry in Mouse Primary Visual Cortex

Q: What does this research mean for the field?

The omission of an expected visual stimulus produces a highly reproducible and control-robust alteration in the neural population geometry of the mouse primary visual cortex (VISp), VISam, and LP, but not in CA1. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Robin Langell

doi:10.5281/zenodo.22232650

September 1, 2026Open Access

Omission of an Expected Visual Stimulus Produces a Reproducible, Control-Robust Alteration of Population Geometry in Mouse Primary Visual Cortex

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Key Points

To determine whether the omission of an expected visual stimulus reliably alters neural population activity geometry in the mouse primary visual cortex.
Analyzed Allen Visual Behavior Neuropixels recordings from 30 sessions in 30 mice using a frozen, locally matched omission-versus-expected population-chart framework.
Evaluated robustness using five falsification controls, four specificity controls, and comparative testing across multiple brain regions (VISp, VISam, LP, and CA1).
Post-minus-pre change in omission-versus-expected chart distance was positive across 30/30 sessions in VISp (median 0.980, p = 9.999×10⁻⁵).
The geometric shift survived all nine control evaluations and replicated after correction in VISam and LP, but was absent in hippocampal region CA1.

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Implication

Neural population analysis reveals robust geometric shifts following omitted visual stimuli in mice, indicating distinct sensory representations for missing expected events.

Abstract

A frozen, locally matched omission-versus-expected population-chart analysis of Allen Visual Behavior Neuropixels (30 sessions, 30 mice). In VISp, the post-minus-pre change in omission-versus-expected chart distance was positive in 30/30 sessions (median 0.980, p = 9.999×10−5), survived five falsification controls and four specificity controls, and replicated after correction in VISam and LP. It was not detected in CA1 under this chart. The result is an operational construct on this dataset, not a biological mechanism or a canonical cross-dataset chart validation.

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Robin Langell (2026) studied this question.

synapsesocial.com/papers/6a9a85e75d9e33f25c63147a https://doi.org/10.5281/zenodo.22232650

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Omission of an Expected Visual Stimulus Produces a Reproducible, Control-Robust Alteration of Population Geometry in Mouse Primary Visual Cortex

Key Points

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Implication

Abstract

Discussion

Cite This Study

Omission of an Expected Visual Stimulus Produces a Reproducible, Control-Robust Alteration of Population Geometry in Mouse Primary Visual Cortex

Key Points

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Implication

Abstract

Discussion

Cite This Study

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