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Electrophysiological analysis reveals failure of trial-to-trial chart transitions to clear sensitivity floors across brain areas, indicating limits for pre-stimulus geometric readouts.
A pre-registered measurement-layer boundary in IBL Reproducible Ephys. A label-blind estimability audit of a discrete trial-to-trial chart-transition operator failed at full scale in VISa/VISam, CA1, and thalamus (median held-out residual fraction 1.001). A disjoint neutral-block decoder recovered stimulus side from the early post-onset population vector in VISa/VISam (median accuracy 0.588, +8.8 pp, pperm = 0.0030), but none of five frozen flow-geometry metrics on pre-stimulus chart transitions was selected. The biased-block prior-side test was not run.
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Robin Langell (2026) studied this question.
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