What question did this study set out to answer?

To evaluate the prognostic utility of systemic inflammation-based indices, particularly the systemic immune-inflammation index, for predicting restenosis and limb outcomes after below-the-knee endovascular revascularization in diabetic patients with critical limb-threatening ischemia.

September 4, 2026BMC Cardiovascular DisordersOpen Access

Prognostic value of systemic inflammatory indices for restenosis and limb salvage after below-the-knee endovascular revascularization in diabetic critical limb-threatening ischemia

Q: What does this research mean for the field?

Higher pre-procedural systemic immune-inflammation index (SII) is independently associated with an increased risk of 6-month restenosis following below-the-knee endovascular revascularization in diabetic patients with critical limb-threatening ischemia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Authors

HGHakan GöçerBalikli Rum Vakfi Hastanesi MKMahmut Kış

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Implication

Retrospective cohort study finds elevated systemic immune-inflammation index predicts six-month restenosis in diabetic critical limb ischemia, highlighting its value for pre-procedural risk scoring.

Key Points

To evaluate the prognostic utility of systemic inflammation-based indices, particularly the systemic immune-inflammation index, for predicting restenosis and limb outcomes after below-the-knee endovascular revascularization in diabetic patients with critical limb-threatening ischemia.
Retrospective cohort study of 210 consecutive diabetic patients undergoing below-the-knee endovascular revascularization for critical limb-threatening ischemia between January 2022 and October 2025.
Calculated systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) within 24 hours before and 48–72 hours after the procedure.
Evaluated 6-month restenosis across 161 technically successful procedures and overall limb salvage using receiver operating characteristic (ROC) curves and multivariable logistic regression.
Technical success was achieved in 76.7% (161/210) of patients, among whom 39.1% (63/161) developed restenosis at 6 months; major amputation occurred in 20.0% (42/210) of the overall cohort.
Patients with restenosis had significantly higher pre-procedural SII than those without (2152.88 ± 765.32 vs. 1344.06 ± 680.17; p < 0.001), showing the strongest discriminative ability among evaluated markers (AUC 0.786, 95% CI 0.717–0.854).
Each 1000-unit increase in pre-procedural SII independently predicted 6-month restenosis in multivariable analysis adjusted for clinical and procedural covariates (adjusted OR 2.31, 95% CI 1.18–4.49; p = 0.014).

Cite This Study

Göçer et al. (2026) studied this question.

synapsesocial.com/papers/6a9a85fa5d9e33f25c63174e https://doi.org/10.1186/s12872-026-06500-6

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Implication

Retrospective cohort study finds elevated systemic immune-inflammation index predicts six-month restenosis in diabetic critical limb ischemia, highlighting its value for pre-procedural risk scoring.

Prognostic value of systemic inflammatory indices for restenosis and limb salvage after below-the-knee endovascular revascularization in diabetic critical limb-threatening ischemia

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Cite This Study

Prognostic value of systemic inflammatory indices for restenosis and limb salvage after below-the-knee endovascular revascularization in diabetic critical limb-threatening ischemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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