Key result
Analysis of 574 stool samples from children with gastroenteritis detected unusual rotavirus strains (G1P6, G2P8, G3P6, G9P4) and mixed infections across four countries.
Cross-Sectional (n=574)
Yes
The detection of unusual rotavirus strains and mixed infections in Central America and the Caribbean emphasizes the need for broad-spectrum rotavirus vaccines.
May necessitate enhanced rotavirus strain surveillance; leaves open whether existing vaccines remain effective against these variants.
In this study, 574 stool samples from children with gastroenteritis were obtained from different hospitals in Costa Rica, Honduras, Nicaragua and the Dominican Republic during 2005-2006. Diarrhea stool samples were analyzed for rotavirus (RV) by ELISA and typed by the RT-PCR-based method. Unusual strains were detected: G1P6, G2P8, G3P6, G9P4, and mixed infections. Recent studies have indicated that unusual human RV strains are emerging as global strains, which has important implications for effective vaccine development. In this context, the next generation of RV vaccines will need to provide adequate protection against diseases caused not only by mixed infections, but also by unusual G/P combinations.
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Bourdett-Stanziola et al. (2010) conducted a cross-sectional in Gastroenteritis (n=574). Rotavirus genotypes was evaluated on Detection of rotavirus genotypes. Analysis of 574 stool samples from children with gastroenteritis detected unusual rotavirus strains (G1P6, G2P8, G3P6, G9P4) and mixed infections across four countries.
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