Key result
Two of 236 RVA-positive samples in Okayama Prefecture were identified as G1P[8]b, with molecular analysis suggesting reassortment between Japanese G1P[8]a and Asian P[8]b viruses.
Observational (n=236)
The Japanese P[8]b rotavirus strain likely emerged from reassortment between local G1P[8]a viruses and unidentified Asian viruses.
Answers are grounded in this paper and cite their sources.
Identifies potential RVA reassortment in Japan; leaves open prevalence and clinical relevance pending larger surveillance studies.
OP354-like P[8] (P[8]b subtype) species A rotaviruses (RVAs) were isolated first time in Japan during a RVA survey in Okayama Prefecture between 2006 and 2009. Two of 236 RVA-positive samples were identified as G1P[8]b by reverse transcription polymerase chain reaction. P[8]b strains (RVA/human-wt/JPN/OH1998/2008/G1P[8]b and RVA/human-wt/JPN/OH2024/2008/G1P[8]b) were isolated only in May, 2008 and both patients infected with P[8]b viruses lived in the same city, suggesting that the prevalence of P[8]b RVAs is limited considerably in Okayama Prefecture. Molecular analysis of four genes (VP4, VP6, VP7, and NSP4 genes) of Japanese P[8]b strains revealed that the VP4 genes of these strains were related closely to those of Southeast Asian and Indian P[8]b strains. In contrast, the VP6, VP7, and NSP4 genes of Japanese P[8]b strains were highly homologous to G1P[8]a strains prevalent in the same area. These results suggest that the Japanese P[8]b strain may be a result of reassortment events between Japanese G1P[8]a viruses and unidentified Asian viruses possessing the P[8]b VP4 gene.
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Kuzuya et al. (2012) conducted an observational in Rotavirus A infection (n=236). OP354-like P[8] (P[8]b subtype) human rotaviruses was evaluated on Identification and molecular characterization of P[8]b strains. Two of 236 RVA-positive samples in Okayama Prefecture were identified as G1P[8]b, with molecular analysis suggesting reassortment between Japanese G1P[8]a and Asian P[8]b viruses.
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