Exercise and Hematopoietic Stem and Progenitor Cells

In Brief The effects of exercise on mature cells of the hematopoietic lineage have been well characterized; however, the effects of exercise on the more primitive cells of the hematopoietic system are unknown. Here, we propose that the benefits of exercise apply to hematopoietic progenitors and that exercise increases hematopoietic stem cell quantity primarily mediated via adaptations in the stem cell niche. The benefits of exercise training extend to progenitor cells in the hematopoietic system and primarily are mediated by alterations in the niche.