Key result
Intravenous thrombolytic therapy with alteplase successfully resolved neurological symptoms in a patient with cerebral infarction associated with left atrial myxoma, without adverse effects.
Why the study?
Does intravenous thrombolytic therapy improve neurological symptoms in a patient with cerebral infarction associated with left atrial myxoma?
Case Report (n=1)
No
Does intravenous thrombolytic therapy improve neurological symptoms in a patient with cerebral infarction associated with left atrial myxoma?
Intravenous thrombolytic therapy can be effective and safely considered in patients with acute cerebral infarction associated with left atrial myxoma if there are no contraindications.
Alteplase may resolve symptoms in myxoma-related stroke; hypothesis-generating case report requiring prospective validation.
A 70-year-old man presented with sudden onset of global aphasia and right hemiplegia. Brain MRI revealed occlusion of the left middle cerebral artery. He was diagnosed as having a hyperacute cerebral infarction. Intravenous thrombolytic therapy was started, and the neurological symptoms were resolved after 11 h. Echocardiography showed a mobile mass in the left atrium, suspicious of a myxoma. The tumor was resected and pathologically diagnosed as a myxoma. In this patient, intravenous thrombolytic therapy was effective, and no adverse effects were observed. This suggests that, even with complications of myxoma, thrombolytic therapy can be considered if there are no contraindications.
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Abé et al. (2011) conducted a case report in Cerebral infarction associated with left atrial myxoma (n=1). Alteplase (rt-PA) was evaluated on Neurological symptom resolution (NIHSS score). Intravenous thrombolytic therapy with alteplase successfully resolved neurological symptoms in a patient with cerebral infarction associated with left atrial myxoma, without adverse effects.
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