Key result
Female survivors of childhood acute lymphoblastic leukemia had significantly greater body fat (32.5% vs 26.3%, p<0.005) and reduced peak oxygen consumption compared with sibling controls.
Why the study?
Does a history of childhood malignancy alter cardiopulmonary response to exercise and adiposity in long-term survivors compared to sibling controls?
Population
88 subjects: 56 long term survivors of childhood malignancy and 32 siblings acting as controls.
Design
Case-control
Authors
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May warrant monitoring adiposity and fitness in female ALL survivors; leaves open causal links and intervention benefits.
Cross-Sectional (n=88)
Does a history of childhood malignancy alter cardiopulmonary response to exercise and adiposity in long-term survivors compared to sibling controls?
Absolute Event Rate: 32.5% vs 26.3%
p-value: p=< 0.005
Long-term survivors of childhood acute lymphoblastic leukemia exhibit reduced exercise capacity and altered cardiopulmonary responses, which may contribute to excess adiposity.
Warner et al. (1997) conducted a cross-sectional in Childhood malignancy (n=88). History of acute lymphoblastic leukaemia (ALL) vs. Sibling controls was evaluated on Body fat percentage in female survivors (p=< 0.005). Female survivors of childhood acute lymphoblastic leukemia had significantly greater body fat (32.5% vs 26.3%, p<0.005) and reduced peak oxygen consumption compared with sibling controls.
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