Key result
Elevated C-reactive protein levels were significantly associated with the occurrence of non-alcoholic fatty liver disease (OR 1.55), which was also linked to lower dietary intake of zinc and vitamin E.
Why the study?
Non-alcoholic fatty liver disease prevalence and progression are mediated by factors correlating with hepatic necroinflammation, prompting analysis of inflammatory markers and related nutritional factors according to NAFLD presence.
Cross-Sectional (n=80)
No
Odds Ratio: 1.55 (95% CI 1.21–2.26)
p-value: p=0.003
NAFLD is associated with increased inflammatory markers and altered nutritional intake, suggesting a potential role for antioxidant and anti-inflammatory nutrients in its management.
Altered inflammatory profiles in NAFLD associate with lower zinc and vitamin E intake; leaves open whether targeted nutrition modifies disease progression.
The prevalence and progression of non-alcoholic fatty liver disease (NAFLD) is mediated via several factors correlating with hepatic necroinflammation (adipokines/cytokines). This study was performed to analyze the level of inflammatory markers according to the presence of NAFLD and to identify related nutritional factors. A total of 80 adults were classified into 2 groups (healthy and NAFLD), and their body composition, blood tests, and eating habits were evaluated. In addition, inflammatory markers (adiponectin, high-sensitivity C-reactive protein [CRP], and tumor necrosis factor-alpha [TNF-α]), nutrient intake status, and dietary quality were compared. The quality of diet was assessed according to the nutrient adequacy ratio and the mean adequacy ratio (MAR). The NAFLD group had a higher body mass index (p < 0.001) than the healthy group and also carried significantly higher CRP levels (p < 0.001) but lower adiponectin (p = 0.001). TNF-α levels increased significantly with fatty liver grade (p = 0.023). The NAFLD group showed significantly higher intake of energy, carbohydrates, iron, sodium, vitamin A and saturated fatty acids, but significantly lower intake of zinc and vitamin E than the healthy group. The MAR values were slightly higher in the NAFLD group but without any significant difference. The levels of adiponectin and vitamin E showed a significant inverse correlation (p < 0.05). Nutritional management of NAFLD patients is important, and the intake of antioxidant and anti-inflammatory nutrients such as zinc and vitamin E should be emphasized.
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Lim et al. (2020) conducted a cross-sectional in Non-alcoholic fatty liver disease (n=80). C-reactive protein (CRP) vs. Lower CRP levels was evaluated on Occurrence of non-alcoholic fatty liver disease (NAFLD) (OR 1.55, 95% CI 1.21-2.26, p=0.003). Elevated C-reactive protein levels were significantly associated with the occurrence of non-alcoholic fatty liver disease (OR 1.55), which was also linked to lower dietary intake of zinc and vitamin E.
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