Key result
Dexmedetomidine added to ropivacaine significantly shortened onset time and prolonged the duration of sensory and motor blocks and post-operative analgesia compared to ropivacaine alone.
Why the study?
Does dexmedetomidine added to ropivacaine improve block characteristics and prolong analgesia in patients undergoing elective upper limb surgeries under supraclavicular brachial plexus block?
RCT (n=80)
Randomly divided
Does dexmedetomidine added to ropivacaine improve block characteristics and prolong analgesia in patients undergoing elective upper limb surgeries under supraclavicular brachial plexus block?
Answers are grounded in this paper and cite their sources.
Adding dexmedetomidine to ropivacaine for supraclavicular brachial plexus block significantly improves block onset and prolongs postoperative analgesia, though it requires monitoring for bradycardia and hypotension.
BACKGROUND : Supraclavicular approach to brachial plexus block is a versatile and reliable regional anesthesia technique and a suitable alternative to general anesthesia for upper limb surgical procedures. Ropivacaine , a long acting local anesthetic, with less tendency for neurotoxicity and cardiotoxicity is a great local anesthetic for the procedure. Use of adjuvant Dexmedetomidine , a potent alpha 2 adrenoreceptor agonist improves the quality of anesthesia as well as intra-operative and post-operative analgesia while maintaining haemodynamic stability, arousable sedation and mild respiratory depression. MATERIALS AND METHODS: Eighty patients aged between 18 and 60 years with ASA grade I or II posted for elective upper limb surgeries were included in the study and were randomly divided into 2 groups with forty patients in each. Group A received 0.5% ropivacaine (31 mL) and Group B received 0.5% ropivacaine + dexmedetomidine 1microgram/kg (31mL). Both groups were compared for onset time and duration of sensory blockade, onset time and duration of motor blockade , total duration of analgesia and associated side effects. CONCLUSION : Dexmedetomidine as an adjuvant to ropivacaine in the supraclavicular brachial plexus block for upper limb surgeries , significantly shortens the onset time and prolongs the duration of sensory and motor blocks, with longer duration of post-operative analgesia , with associated significant sedation and a few manageable side effects like bradycardia and hypotension.
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Pathak et al. (2021) conducted an RCT in Elective upper limb surgeries (n=80). Dexmedetomidine as an adjuvant to ropivacaine vs. 0.5% ropivacaine (31 mL) was evaluated on Onset time and duration of sensory and motor blockade, and total duration of analgesia. Dexmedetomidine added to ropivacaine significantly shortened onset time and prolonged the duration of sensory and motor blocks and post-operative analgesia compared to ropivacaine alone.
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