Key result
Host factor CPSF6 directly interacts with viral NP1, mediating its nuclear import and playing a role in the maturation of capsid protein-encoding mRNAs in the nucleus.
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CPSF6-NP1 interaction identifies a potential host target for HBoV1; leaves open antiviral efficacy and clinical translation.
Human bocavirus 1 (HBoV1) is one of the significant pathogens causing acute respiratory tract infections in young children worldwide. HBoV1 encodes a small nonstructural protein (NP1) that plays an important role in the maturation of viral mRNAs encoding capsid proteins as well as in viral DNA replication. Here, we identified a critical host factor, CPSF6, that directly interacts with NP1, mediates the nuclear import of NP1, and plays a role in the maturation of capsid protein-encoding mRNAs in the nucleus. The identification of the direct interaction between viral NP1 and host CPSF6 provides new insights into the mechanism by which a viral small nonstructural protein facilitates the multiple regulation of viral gene expression and replication and reveals a novel target for potent antiviral drug development.
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Wang et al. (2019) studied Human bocavirus 1 (HBoV1) infection. Host factor CPSF6 directly interacts with viral NP1, mediating its nuclear import and playing a role in the maturation of capsid protein-encoding mRNAs in the nucleus.
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