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The International Association for the Study of Pain (IASP) defines trigeminal neuralgia as a sudden, unilateral, severe, brief, stabbing, recurrent episode of pain in the distribution of one or more branches of the trigeminal nerve. Trigeminal neuralgia (TN) can be distinguished in classical TN and symptomatic TN Classical TN is due to a vascular compression of the trigeminal root by tortuous or aberrant vessels. Symptomatic TN can be related to cerebello-pontine angle tumours which compress the trigeminal nerve root. Multiple sclerosis (MS) is typically associated with TN (2-4% of patients with TN)
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Andrea Truini (2015) studied this question.
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