Key result
Ultrafiltration volume ≤3% of dry weight is linked to better myocardial work indices during haemodialysis.
Why the study?
The study aimed to investigate the impact of different ultrafiltration volumes during haemodialysis on cardiac function and myocardial work indices in patients with kidney failure undergoing maintenance haemodialysis.
Does an ultrafiltration volume of ⩽3% of dry weight during haemodialysis mitigate adverse impacts on myocardial work and cardiac function compared to >3% in patients with kidney failure?
Observational (n=58)
No
Does an ultrafiltration volume of ⩽3% of dry weight during haemodialysis mitigate adverse impacts on myocardial work and cardiac function compared to >3% in patients with kidney failure?
p-value: p=<0.05
Limiting ultrafiltration volume to ⩽3% of dry weight during haemodialysis may mitigate acute adverse effects on myocardial work and cardiac mechanics.
Objective: This study aimed to investigate the impact of different ultrafiltration (UF) volumes (UFVs) during haemodialysis (HD) on cardiac function and myocardial work (MW) indices in patients with kidney failure (KF) undergoing maintenance HD (MHD). Methods: A total of 58 participants were enrolled. The patients with KF were stratified into two groups based on their UFV. Data were collected between July 2023 and August 2024 at the Second Affiliated Hospital of Baotou Medical College. Cardiac parameters were measured using echocardiography before and after HD. Results: Compared with healthy controls, the KF groups exhibited significantly elevated systolic blood pressure, heart rate and early diastolic mitral inflow velocity to early diastolic mitral annulus velocity ratio, along with reduced global longitudinal strain (GLS), global work efficiency (GWE), global constructive work (GCW) and global work index (GWI; all p < 0.05). Post-HD, the ⩽3% group showed improvements in GLS and GWE, whereas GCW, global wasted work and GWI decreased significantly ( p < 0.05). In contrast, the >3% group experienced reductions in left atrial and ventricular size, GCW, GWE and GWI following dialysis ( p < 0.05), without significant changes in GLS. Conclusion: Ultrafiltration volumes during HD significantly affect MW and cardiac function. Ultrafiltration ⩽3% of dry weight appears to mitigate the adverse impact on cardiac parameters, offering potential clinical value for optimising HD protocols.
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Li et al. (2025) conducted an observational in Kidney failure undergoing maintenance haemodialysis (n=58). Ultrafiltration volume ⩽3% of dry weight vs. Ultrafiltration volume >3% of dry weight was evaluated on Cardiac function and myocardial work indices (GLS, GWE, GCW, GWI) (p=<0.05). Ultrafiltration volume ⩽3% of dry weight during haemodialysis improved global longitudinal strain and global work efficiency, mitigating adverse impacts on cardiac parameters (p<0.05).
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