Key result
Among 16 patients with newly diagnosed non-Hodgkin's lymphoma and cardiac involvement, first-line therapy resulted in a 79% response rate and a median overall survival of 3.5 years.
Case Report (n=16)
Yes
Cardiac involvement in newly diagnosed non-Hodgkin's lymphoma is extremely rare (0.1%) but can be effectively managed with systemic chemotherapy, yielding long-term survival in about half of the patients.
Supports CHOP for asymptomatic cardiac ALCL; leaves open larger studies on NHL cardiac involvement.
We report a rare case of anaplastic large cell ALK+ lymphoma (ALCL) with initial asymptomatic cardiac involvement. A 59-year-old male with infiltration of the right ventricular wall underwent standard combined chemotherapy (CHOP) and achieved remission without significant cardiac impairment. Additionally, we report the actual incidence of cardiac lymphoma in newly diagnosed non-Hodgkin Lymphomas (NHLs). In total, 16 patients with cardiac lymphoma were found (0.1% NHLs) in the Czech Lymphoma Study Group database. DLBCL was the most frequent histology subtype (50%), and ALCL was identified in 12.5% of cases. At initial diagnosis, the median age was 55.5 (range 21-74) years and 59% were men. None of the 16 patients with cardiac involvement had isolated heart lymphoma. The response to first-line therapy was 79% in 14/16 evaluable patients. The median progression-free survival and overall survival were nearly the sameapproximately 3.5 years (range; 0.05-16.7ys), while the median follow up was 4 years.
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Lobello et al. (2017) conducted a case report in Cardiac involvement in newly diagnosed non-Hodgkin's lymphoma (n=16). First-line chemotherapy (CHOP-like regimens) was evaluated on Response to first-line therapy. Among 16 patients with newly diagnosed non-Hodgkin's lymphoma and cardiac involvement, first-line therapy resulted in a 79% response rate and a median overall survival of 3.5 years.
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